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Gambling with the Moon

~ A journey through infertility, IVF, and hope.

Gambling with the Moon

Daily Archives: February 18, 2012

Advanced IVF for those ready to dip your toes in….

18 Saturday Feb 2012

Posted by gamblingwiththemoon in Infertility, IVF

≈ 1 Comment

So I wrote earlier about the basic IVF process, but I wanted to go into a little more detail about what will happen retrieval and transfer-for those of you that are interested.  So the day on the egg retrieval, they will put me under and take out all those eggs that we have been stimulating. They will place the eggs and sperm in a dish to do their thing.  Once the sperm enters the egg, it is now called a zygote.  Remember Biology…were you awake that day?  I semi-was….Remember:  My gametes meet his gametes and make a zygote.  Here is a photo….the two little circles are the genetic material from each person!  So cool….During IVF, all these processes that normally take place in the fallopian tubes (of which mine are struggling), are now taking place in a little petri dish in a lab. Those cells start to divide in the dish.  After three days in the cultured environment, the embryos have hopefully divided into 6-8 cells.  

At this point, good quality embryos may be placed back in the uterus, where they will float around for a couple of days before implanting in the uterine wall.  Recent breakthroughs in IVF technology have allowed us to potentially go one step further in the culturing process, therefore increasing chances of implant-worthy embryos.  Now, instead of placing the embryos back in the body after three days, extremely high quality embryos stay in the lab culture environment for two extra days in the hopes that they will become blastocysts.  Blastocysts are the Holy Grail of IVF. Ready to immediately implant and proven to be able to withstand the test of time/development, blastocysts have an excellent chance of resulting in pregnancy. Here is a photo…So these guys are your optimal embryos to transfer, but you run a slight risk of leaving them in the culture environment for the two extra days to see if they will become blastocysts.  No matter how far science has come, the embryos still thrive better in the uterine environment than in the lab. Therefore, the embryologist has to make the decision to either transfer at day three or risk the extra two days to get the embryos to the super sticky blastocyst stage. This will depend on quality, grading, and # of embryos available.   Just one of the many gambles we will take during this adventure!

Day 5…Bump it up

18 Saturday Feb 2012

Posted by gamblingwiththemoon in Uncategorized

≈ 1 Comment

I went to the clinic today for the blood draw to check E2 Levels.  They want it at around 200 to 250.  If it is a lot higher than that, it means you are responding too much to the medication.  THe concern here is that on can get Ovarian Hyperstimulation Syndrome (hyperlinked to Wiki page), a painful condition which can cause hospitalization and cycle cancellation if severe.  If the e2 levels are too low, you are not responding to the medication enough.  If less than 75, the chances for a successful IVF cycle or pregnancy significantly decrease.  So your doctor does a delicate dance of trying to push your body with medication enough to produce lots of good eggs, but not so much that your system hyperstimulates.

My levels were at 178.3, just shy of the perfect 200.  This is no big deal at all, it just translates into an increase in the dosage of the injections.  My medication protocol is very conservative at this point.  I was on 75 menapur and 75 follistim.  On fertility forums (a great resource and support network for women going through this procedure)  I have seen women taking as high as 600 follistim.  Such high dosages generally correlate to issues surrounding egg quality (indicated by an AMH or Anti-Mullerian Hormone test)  and egg reserve (# of eggs you have left)-neither of which of are my particular issues.  As far as we know, my issue is purely mechanical-bad tubes-not hormonal.  So my medication protocol started out as more conservative to lower the risk of Ovarian Hyperstimulation Syndrome.  With my levels on day five being just shy of the 200, my doctor has upped my Follistim dosage to 100 and kept my Menapur dosage at 75.  We will continue this particular protocol tonight and tomorrow night, then I will return on Monday for another E2 and ultrasound….we will get to see how many of these bad boys are actually cookin’!  THAT I am excited about!!!!

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